Effect of Membrane Curvature-Modifying Lipids on Membrane Fusion by Tick-Borne Encephalitis Virus
نویسندگان
چکیده
منابع مشابه
Effect of membrane curvature-modifying lipids on membrane fusion by tick-borne encephalitis virus.
Enveloped viruses enter cells by fusion of their own membrane with a cellular membrane. Incorporation of inverted-cone-shaped lipids such as lysophosphatidylcholine (LPC) into the outer leaflet of target membranes has been shown previously to impair fusion mediated by class I viral fusion proteins, e.g., the influenza virus hemagglutinin. It has been suggested that these results provide evidenc...
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Membrane fusion of the flavivirus tick-borne encephalitis virus is triggered by the mildly acidic pH of the endosome and is mediated by envelope protein E, a class II viral fusion protein. The low-pH trigger induces an oligomeric rearrangement in which the subunits of the native E homodimers dissociate and the monomeric subunits then reassociate into homotrimers. Here we provide evidence that m...
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increased during the past 13 years (6). This trend is accompanied by an increase in the total number of periprosthetic joint infections, even though the overall percentage of this complication is low (7). The most commonly isolated organisms in periprosthetic joint infections are gram-positive cocci, specifically Staphylococcus aureus and S. epidermidis (8). In a retrospective review, Moran et ...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2004
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.78.16.8536-8542.2004